Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats

Letteria Minutoli; Salvatore Arena; Giulio Bonvissuto; Alessandra Bitto; Francesca Polito; Natasha Irrera; Francesco Arena; Eugenia Fragalà; Carmelo Romeo; Piero Antonio Nicotina; Carmine Fazzari; Herbert Marini; Alessandra Implatini; Silvia Grimaldi; Noemi Cantone; Vincenzo Di Benedetto; Francesco Squadrito; Domenica Altavilla; Giuseppe Morgia

doi:10.1016/j.fertnstert.2010.07.1047

Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats

Fertil Steril. 2011 Mar 15;95(4):1510-3. doi: 10.1016/j.fertnstert.2010.07.1047. Epub 2010 Aug 24.

Affiliation

¹ Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy.

PMID: 20797711
DOI: 10.1016/j.fertnstert.2010.07.1047

Abstract

In rat experimental varicocele, polydeoxyribonucleotide (PDRN) induces vascular endothelial growth factor (VEGF) production, thereby enhancing testicular function. This may point to a new therapeutic approach in human varicocele.

Publication types

Comparative Study

MeSH terms

Animals
Male
Polydeoxyribonucleotides / pharmacology*
Polydeoxyribonucleotides / therapeutic use*
Protective Agents / pharmacology
Protective Agents / therapeutic use
Random Allocation
Rats
Rats, Sprague-Dawley
Receptor, Adenosine A2A / metabolism*
Testis / pathology
Up-Regulation / physiology*
Varicocele / metabolism*
Varicocele / pathology
Varicocele / prevention & control*
Vascular Endothelial Growth Factor A / biosynthesis*

Substances

Polydeoxyribonucleotides
Protective Agents
Receptor, Adenosine A2A
Vascular Endothelial Growth Factor A