Abstract
Background:
Standard treatment of glioblastoma multiforme consists of postoperative radiochemotherapy with temozolomide, followed by a 6-month chemotherapy. Serious hematologic complications are rarely reported.
Case report and results:
The authors present the case of a 61-year-old female patient with glioblastoma multiforme treated with external-beam radiation therapy and concomitant temozolomide. After completion of treatment, the patient developed symptoms of serious aplastic anemia that eventually led to death due to prolonged neutro- and thrombocytopenia followed by infectious complications.
Conclusion:
Lethal complications following temozolomide are, per se, extremely rare, however, a total of four other cases of aplastic anemia have been reported in the literature so far.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Anemia, Aplastic / chemically induced*
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Anemia, Aplastic / mortality*
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Antineoplastic Agents, Alkylating / therapeutic use
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Antineoplastic Agents, Alkylating / toxicity*
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Blood Cell Count
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Brain Neoplasms / drug therapy*
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Brain Neoplasms / radiotherapy*
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Cause of Death
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Combined Modality Therapy
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Cranial Irradiation
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Dacarbazine / analogs & derivatives*
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Dacarbazine / therapeutic use
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Dacarbazine / toxicity
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Dose Fractionation, Radiation
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Female
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Frontal Lobe*
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Glioblastoma / drug therapy*
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Glioblastoma / radiotherapy*
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Hemorrhagic Disorders / chemically induced
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Hemorrhagic Disorders / mortality
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Humans
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Magnetic Resonance Imaging
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Middle Aged
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Parietal Lobe*
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Temozolomide
Substances
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Antineoplastic Agents, Alkylating
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Dacarbazine
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Temozolomide