Impact of long-term storage on stability of standard DNA for nucleic acid-based methods

J Clin Microbiol. 2010 Nov;48(11):4260-2. doi: 10.1128/JCM.01230-10. Epub 2010 Sep 1.

Abstract

Real-time PCR is dependent upon a calibration function for quantification. While long-term storage of standards saves cost and time, solutions of DNA are prone to degradation. We present here the benchmark treatment for preservation of DNA standards, involving storage in 50% glycerol-double-distilled water, whereby a deviation of 0.2 threshold cycle (C(T)) values resulted after 100 days of storage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clinical Laboratory Techniques / methods
  • Clinical Laboratory Techniques / standards*
  • Cryopreservation / methods
  • DNA / analysis*
  • DNA / genetics
  • Polymerase Chain Reaction / methods
  • Polymerase Chain Reaction / standards*
  • Preservation, Biological / methods*
  • Reference Standards*
  • Specimen Handling / methods*

Substances

  • DNA