Role of titin in skeletal muscle function and disease

Coen A C Ottenheijm; Henk Granzier

doi:10.1007/978-1-4419-6366-6_6

Role of titin in skeletal muscle function and disease

Adv Exp Med Biol. 2010:682:105-22. doi: 10.1007/978-1-4419-6366-6_6.

Authors

Coen A C Ottenheijm¹, Henk Granzier

Affiliation

¹ Department of Physiology, University of Arizona, Tucson, AZ, USA.

PMID: 20824522
DOI: 10.1007/978-1-4419-6366-6_6

Abstract

This review covers recent developments in the titin field. Most recent reviews have discussed titin's role in cardiac function: here we will mainly focus on skeletal muscle, and discuss recent advances in the understanding of titin's role in skeletal muscle function and disease.

MeSH terms

Biomechanical Phenomena / physiology
Carrier Proteins / physiology
Connectin
Elasticity
Humans
Muscle Proteins / physiology*
Muscle, Skeletal / physiology*
Muscular Diseases / physiopathology*
Protein Isoforms / physiology
Protein Kinases / physiology*
Pulmonary Disease, Chronic Obstructive / physiopathology
Sarcomeres / physiology

Substances

Carrier Proteins
Connectin
Muscle Proteins
Protein Isoforms
TTN protein, human
Protein Kinases