Pseudo-outbreak of adenovirus infection in a neonatal intensive care unit due to a false-positive antigen detection test

J Clin Microbiol. 2010 Nov;48(11):4251-2. doi: 10.1128/JCM.01262-10. Epub 2010 Sep 8.

Abstract

Twenty-eight of 56 infants in a neonatal intensive care unit had stools positive for adenovirus by the Sure-Vue adenovirus test. Virus cultures of conventionally processed and chloroform-extracted stool samples, as well as conventional and real-time PCR tests, were negative for adenovirus. The cause for the 50% false-positive rate with the antigen test was not determined.

MeSH terms

  • Adenoviridae / isolation & purification*
  • Adenovirus Infections, Human / diagnosis*
  • Adenovirus Infections, Human / epidemiology
  • Adenovirus Infections, Human / virology
  • Antigens, Viral / analysis*
  • Cross Infection / diagnosis*
  • Cross Infection / epidemiology
  • Cross Infection / virology
  • Disease Outbreaks*
  • False Positive Reactions*
  • Feces / virology
  • Female
  • Humans
  • Immunoassay / methods
  • Infant
  • Intensive Care, Neonatal
  • Male
  • Polymerase Chain Reaction
  • Virology / methods*
  • Virus Cultivation

Substances

  • Antigens, Viral