Synthesis of chiral tertiary trifluoromethyl alcohols by asymmetric nitroaldol reaction with a Cu(II)-bisoxazolidine catalyst

Hanhui Xu; Christian Wolf

doi:10.1039/c0cc02378g

Synthesis of chiral tertiary trifluoromethyl alcohols by asymmetric nitroaldol reaction with a Cu(II)-bisoxazolidine catalyst

Chem Commun (Camb). 2010 Nov 14;46(42):8026-8. doi: 10.1039/c0cc02378g. Epub 2010 Sep 22.

Authors

Hanhui Xu¹, Christian Wolf

Affiliation

¹ Department of Chemistry, Georgetown University, Washington, DC 20057, USA.

PMID: 20859576
DOI: 10.1039/c0cc02378g

Abstract

A highly enantioselective and diastereoselective copper(II)-bisoxazolidine catalyzed nitroaldol reaction with aliphatic and aromatic trifluoromethyl ketones is described.