Salmonella typhimurium infections encountered at the neighbourhood of Bursa since January 1987 were evaluated in regard to the antibiotic resistance and treatment. High proportion of resistance was determined to the antibacterial agents such as ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, tetracycline and more sensitivity to ofloxacin, amikacin, ceftriaxone and cefotaxime was established in 383 Salmonella typhimurium strains isolated within two years of period. No antibiotic therapy was required to adult uncomplicated patients. A combination therapy with cefotaxime and amikacin was found to be satisfactory in the newborn cases with septicemia.