Structure-activity relationship studies of CNS agents. Part 1: The Free-Wilson analysis of acute toxicity and sedative effect of some 1,2,3,4-tetrahydro-beta-carbolines

Pharmazie. 1990 Oct;45(10):765-7.

Abstract

It has been found that 3-alkoxycarbonyl-beta-carbolines are almost non-toxic and showed a sedative effect. The quantitative relationship between the structure of some 1,2,3,4-tetrahydro-beta-carbolines and their acute toxicity and sedative effect was found using the Free-Wilson approach.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics
  • Animals
  • Anticonvulsants / chemical synthesis
  • Body Temperature / drug effects
  • Carbolines / chemical synthesis*
  • Carbolines / pharmacology
  • Carbolines / toxicity
  • Hypnotics and Sedatives / chemical synthesis*
  • Hypnotics and Sedatives / pharmacology
  • Hypnotics and Sedatives / toxicity
  • Lethal Dose 50
  • Male
  • Mice
  • Motor Activity / drug effects
  • Rats
  • Rats, Inbred Strains
  • Stereotyped Behavior / drug effects
  • Structure-Activity Relationship

Substances

  • Analgesics
  • Anticonvulsants
  • Carbolines
  • Hypnotics and Sedatives