From atom to brain: applications of molecular imaging to neurosurgery

World Neurosurg. 2010 May;73(5):477-85. doi: 10.1016/j.wneu.2010.02.058.

Abstract

Molecular imaging is a field born out of the happy marriage of molecular biology and radiology. The first installment of this two-part series on molecular imaging demonstrated basic principles for practitioners in the field of the neurosciences. This installment seeks to provide some illustrative examples, insights, and specific applications to the neurosciences. The fields of functional neurosurgery including the treatment of neuropsychiatric disorders, novel treatments and imaging of tumors, neuroregenerative medicine, and nanotechnology in vascular disorders are covered. Finally, we give some parting thoughts on the future of molecular imaging, including advances in the imaging of neurodegenerative disorders.

Publication types

  • Review

MeSH terms

  • Benzamides
  • Brain / anatomy & histology*
  • Brain / diagnostic imaging
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / surgery
  • Cerebrovascular Disorders / diagnostic imaging
  • Cerebrovascular Disorders / surgery
  • Dementia / diagnostic imaging
  • Dementia / surgery
  • Humans
  • Magnetic Resonance Imaging
  • Molecular Imaging / methods*
  • Nanotechnology
  • Neurodegenerative Diseases / diagnostic imaging
  • Neurodegenerative Diseases / surgery
  • Neurosurgery / methods*
  • Neurosurgical Procedures
  • Pyrrolidines
  • Quantum Dots
  • Radiography
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Radiosurgery
  • Receptors, Dopamine / metabolism

Substances

  • Benzamides
  • N-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide
  • Pyrrolidines
  • Radiopharmaceuticals
  • Receptors, Dopamine