[Topical imiquimod for the treatment of anogenital warts in an infant]

Ann Dermatol Venereol. 2010 Oct;137(10):622-5. doi: 10.1016/j.annder.2010.06.025. Epub 2010 Aug 26.
[Article in French]

Abstract

Background: Treatment of anogenital warts (AW) in children and infants is painful because of the destructive techniques involved, as a result of which general anaesthesia may be required. For adults, topical imiquimod is an efficient and well-tolerated product used for these lesions. Here, we report a case demonstrating the benefits of topical imiquimod in the treatment of AW in infant.

Patients and methods: A ten-month-old infant was presenting large AW in the inguinal and perianal folds for a period of two months, which persisted despite one month of treatment with podophyllotoxin. After a month of daily application of imiquimod, the AW was completely cured, with no recurrence at six months.

Discussion: In the literature, we found four similar case reports concerning the efficacy and safety of topical imiquimod for AW in infants. Although topical imiquimod is not licensed for paediatric use, these case reports highlight the benefits of this approach in infants.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Aminoquinolines / administration & dosage*
  • Aminoquinolines / adverse effects
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / adverse effects
  • Anus Diseases / diagnosis
  • Anus Diseases / drug therapy*
  • Anus Diseases / pathology
  • Condylomata Acuminata / diagnosis
  • Condylomata Acuminata / drug therapy*
  • Condylomata Acuminata / pathology
  • Drug Eruptions / diagnosis
  • Follow-Up Studies
  • Genital Diseases, Male / diagnosis
  • Genital Diseases, Male / drug therapy*
  • Genital Diseases, Male / pathology
  • Hospitalization
  • Humans
  • Imiquimod
  • Infant
  • Inguinal Canal
  • Male
  • Skin / pathology
  • Skin Ulcer / chemically induced
  • Skin Ulcer / diagnosis
  • Treatment Outcome

Substances

  • Aminoquinolines
  • Antineoplastic Agents
  • Imiquimod