Generation of protein-derived redox cofactors by posttranslational modification

Mol Biosyst. 2011 Jan;7(1):29-37. doi: 10.1039/c005311b. Epub 2010 Oct 8.

Abstract

Redox enzymes which catalyze the oxidation and reduction of substrates are ubiquitous in nature. These enzymes typically possess exogenous cofactors to allow them to perform catalytic functions which cannot be accomplished using only amino acid residues. It is now evident that nature also employs an alternative strategy of generating catalytic and redox-active sites in proteins by posttranslational modification of amino acid residues. This review describes the structures and functions of several of these protein-derived cofactors and the diverse mechanisms of posttranslational modification through which they are generated.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Coenzymes / chemistry
  • Coenzymes / metabolism*
  • Humans
  • Oxidation-Reduction
  • Protein Processing, Post-Translational / physiology*
  • Proteins / chemistry
  • Proteins / metabolism*

Substances

  • Coenzymes
  • Proteins