Phospholipase A2 inhibitors (βPLIs) are encoded in the venom glands of Lachesis muta (Crotalinae, Viperidae) snakes

Rebeca Mascarenhas Lima; Maria Inácia Estevão-Costa; Inácio L M Junqueira-de-Azevedo; Paulo Lee Ho; Marcelo Ribeiro Vasconcelos Diniz; Consuelo Latorre Fortes-Dias

doi:10.1016/j.toxicon.2010.10.005

Phospholipase A2 inhibitors (βPLIs) are encoded in the venom glands of Lachesis muta (Crotalinae, Viperidae) snakes

Toxicon. 2011 Jan;57(1):172-5. doi: 10.1016/j.toxicon.2010.10.005. Epub 2010 Oct 13.

Authors

Rebeca Mascarenhas Lima¹, Maria Inácia Estevão-Costa, Inácio L M Junqueira-de-Azevedo, Paulo Lee Ho, Marcelo Ribeiro Vasconcelos Diniz, Consuelo Latorre Fortes-Dias

Affiliation

¹ Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias (FUNED), Rua Conde Pereira Carneiro 80, CEP 30510-010, Belo Horizonte, MG, Brazil.

PMID: 20950638
DOI: 10.1016/j.toxicon.2010.10.005

Abstract

Phospholipase A(2) inhibitors (PLIs) are glycoproteins secreted by snake liver into the circulating blood aiming the self-protection against toxic venom phospholipases A(2). In the present study, we describe the first complete nucleotide sequence of a βPLI from venom glands of a New World snake, Lachesis muta. The deduced primary structure was compared to other known βPLIs and recent literature findings of other possible roles of PLIs in snakes are discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
Bothrops / metabolism*
Crotalid Venoms / metabolism*
Electrophoresis, Agar Gel
Enzyme Inhibitors
Exocrine Glands / metabolism*
Group IV Phospholipases A2 / antagonists & inhibitors*
Group IV Phospholipases A2 / chemistry
Group IV Phospholipases A2 / genetics
Molecular Sequence Data

Substances

Crotalid Venoms
Enzyme Inhibitors
Group IV Phospholipases A2