Primary systemic therapy for operable breast cancer patients: the need for the new generation of trial design

MeSH terms

• Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
• Breast Neoplasms / drug therapy*
• Breast Neoplasms / mortality
• Breast Neoplasms / pathology
• Breast Neoplasms / surgery*
• Chemotherapy, Adjuvant
• Clinical Trials as Topic / methods
• Disease-Free Survival
• Evidence-Based Medicine
• Female
• Humans
• Lymphatic Metastasis
• Mastectomy*
• Neoadjuvant Therapy
• Neoplasm Staging
• Neoplasm, Residual
• Patient Selection
• Research Design
• Risk Assessment
• Risk Factors
• Time Factors
• Treatment Outcome
• Tumor Burden