Abstract
The intracerebral injection of β-amyloid-containing brain extracts can induce cerebral β-amyloidosis and associated pathologies in susceptible hosts. We found that intraperitoneal inoculation with β-amyloid-rich extracts induced β-amyloidosis in the brains of β-amyloid precursor protein transgenic mice after prolonged incubation times.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alzheimer Disease / metabolism
-
Alzheimer Disease / pathology
-
Amyloid beta-Peptides / administration & dosage
-
Amyloid beta-Peptides / chemistry*
-
Amyloid beta-Peptides / metabolism
-
Animals
-
Brain / blood supply
-
Brain / pathology*
-
Brain Chemistry
-
Cerebral Amyloid Angiopathy / metabolism
-
Cerebral Amyloid Angiopathy / pathology
-
Female
-
Injections, Intraperitoneal
-
Mice
-
Mice, Transgenic
-
Plaque, Amyloid / pathology
-
Prions / chemistry
-
Prions / metabolism
-
Protein Folding
-
Time Factors
Substances
-
Amyloid beta-Peptides
-
Prions