Chiral bicycle imidazole nucleophilic catalysts: rational design, facile synthesis, and successful application in asymmetric Steglich rearrangement

J Am Chem Soc. 2010 Nov 17;132(45):15939-41. doi: 10.1021/ja109069k. Epub 2010 Oct 26.

Abstract

A new type of chiral bicycle imidazole nucleophilic catalyst was rationally designed, facilely synthesized, and successfully applied in an asymmetric Steglich rearrangement with good to excellent yield and enantioselectivity at ambient temperature. Moreover, it can be easily recycled with almost no reduction of catalytic efficiency. This is the first example for the successful chiral imidazole nucleophilic catalyst without H-bonding assistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Hydrogen Bonding
  • Imidazoles / chemical synthesis
  • Imidazoles / chemistry*
  • Pyrroles / chemical synthesis*
  • Pyrroles / chemistry
  • Stereoisomerism

Substances

  • 6,7-dihydro-5H-pyrrolo(1,2-a)imidazole
  • Imidazoles
  • Pyrroles