Abstract
The electronic properties of graphene can be modulated by charged lipid bilayer adsorbing on the surface. Biorecognition events which lead to changes in membrane integrity can be monitored electrically using an electrolyte-gated biomimetic membrane-graphene transistor. Here, we demonstrate that the bactericidal activity of antimicrobial peptides can be sensed electrically by graphene based on a complex interplay of biomolecular doping and ionic screening effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antimicrobial Cationic Peptides / chemistry
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Antimicrobial Cationic Peptides / pharmacology
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Biomimetic Materials / chemistry*
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Biosensing Techniques
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Cell Membrane / chemistry
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Cell Membrane / drug effects
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Electrons*
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Gram-Negative Bacteria / cytology
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Gram-Negative Bacteria / drug effects
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Graphite / chemistry*
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Lipid Bilayers / chemistry*
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Molecular Sequence Data
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Surface Properties
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Transistors, Electronic
Substances
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Antimicrobial Cationic Peptides
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Lipid Bilayers
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Graphite