Immediate and longer term immunogenicity of a single dose of the combined haemophilus influenzae type B-Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age

Pediatr Infect Dis J. 2011 Apr;30(4):340-2. doi: 10.1097/INF.0b013e31820013d2.

Abstract

Hib-primed but MenC-naive toddlers (N = 433) were randomized to receive 1 dose of Hib-MenC-TT or separate Hib-TT and MenC-CRM197 vaccines. One month later, noninferiority was demonstrated for serum bactericidal anti-MenC antibodies (rSBA) and Hib antipolyribosylribitol phosphate (PRP) antibodies; >99% in both groups had rSBA titer ≥ 8 or anti-PRP concentration ≥ 0.15 μg/mL. After 12 months, rSBA titer ≥ 8 persisted in 86.7% and 76.4%, and anti-PRP concentration ≥ 0.15 μg/mL persisted in 98.8% and 100% of children, respectively.

Trial registration: ClinicalTrials.gov NCT00326118.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / blood
  • Blood Bactericidal Activity
  • Haemophilus Vaccines / administration & dosage
  • Haemophilus Vaccines / immunology*
  • Haemophilus influenzae type b / immunology*
  • Humans
  • Immunization, Secondary / methods*
  • Infant
  • Meningococcal Vaccines / administration & dosage
  • Meningococcal Vaccines / immunology*
  • Neisseria meningitidis, Serogroup C / immunology*
  • Tetanus Toxoid / administration & dosage
  • Tetanus Toxoid / immunology*
  • Time Factors
  • Vaccines, Combined / administration & dosage
  • Vaccines, Combined / immunology
  • Vaccines, Conjugate / administration & dosage
  • Vaccines, Conjugate / immunology

Substances

  • Antibodies, Bacterial
  • Haemophilus Vaccines
  • Meningococcal Vaccines
  • Tetanus Toxoid
  • Vaccines, Combined
  • Vaccines, Conjugate

Associated data

  • ClinicalTrials.gov/NCT00326118