IL-17 family member cytokines: regulation and function in innate immunity

Cytokine Growth Factor Rev. 2010 Dec;21(6):413-23. doi: 10.1016/j.cytogfr.2010.10.002. Epub 2010 Nov 11.

Abstract

Recently, the IL-17 family member cytokines have become prominent subjects of investigation. IL-17 (IL-17A) is the best-described member of this family where its production has been mainly attributed to a specialized T helper subset of the adaptive immune response termed Th17. However, recent research on this and other Th17 cytokines has revealed new sources and functions of IL-17 family members in the innate immune response. This review will highlight recent advances in the field of IL-17 family member cytokines and will predominantly focus on the innate regulation and function of IL-17, IL-17F, and IL-25.

Publication types

  • Review

MeSH terms

  • Helminthiasis / prevention & control
  • Humans
  • Hypersensitivity / immunology
  • Immunity, Innate / physiology*
  • Inflammation / etiology
  • Interleukin-17 / immunology
  • Interleukin-17 / physiology*
  • Killer Cells, Natural / physiology
  • Lung Diseases / etiology
  • Macrophages / physiology
  • Natural Killer T-Cells
  • Nuclear Receptor Subfamily 1, Group F, Member 3 / physiology
  • Th17 Cells / physiology*

Substances

  • IL25 protein, human
  • Interleukin-17
  • Nuclear Receptor Subfamily 1, Group F, Member 3