Daily chlorohexidine gluconate bathing with impregnated cloths results in statistically significant reduction in central line-associated bloodstream infections

Am J Infect Control. 2010 Dec;38(10):817-21. doi: 10.1016/j.ajic.2010.06.005.

Abstract

Background: Central line-associated bloodstream infections (CLABSI) contribute to increased morbidity, mortality, length of stay, and excessive cost of care.

Methods: This study was an observational cohort study using historical controls in the setting of a 9-bed surgical intensive care unit in a Level I trauma center; all patients admitted or transferred into the unit were enrolled in the study.

Objectives: A quality improvement intervention protocol was instituted to reduce CLABSI incidence with a 3-month effectiveness study using 2% chlorhexidine gluconate-impregnated cloths for daily patient bathing; education of surgical intensive care unit staff on changes to CLABSI prevention protocol and all existing CLABSI prevention policies and bundles already in place; and compliance monitoring and documentation.

Results: The 3-month effectiveness study showed a decrease in CLABSI rates from 12.07 CLABSIs per 1000 central line-days to 3.17 CLABSIs per 1000 central line-days (73.7% rate reduction; P = .0358).

Conclusion: CLABSI incidence rates were reduced in a high-risk patient population using evidence-based prevention bundles and implementing daily bathing with 2% chlorhexidine gluconate nonrinse cloths.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catheter-Related Infections / epidemiology
  • Catheter-Related Infections / prevention & control*
  • Catheterization, Central Venous / adverse effects
  • Catheters, Indwelling / adverse effects
  • Chlorhexidine / administration & dosage
  • Chlorhexidine / analogs & derivatives*
  • Cohort Studies
  • Cross Infection / epidemiology
  • Cross Infection / prevention & control*
  • Disinfectants / administration & dosage*
  • Humans
  • Incidence
  • Infection Control / methods*
  • Intensive Care Units
  • Treatment Outcome

Substances

  • Disinfectants
  • chlorhexidine gluconate
  • Chlorhexidine