CCND1 and MET genomic amplification during malignant transformation of a giant cell tumor of bone

J Clin Oncol. 2011 Feb 1;29(4):e86-9. doi: 10.1200/JCO.2010.31.4286. Epub 2010 Nov 22.

Authors

Esma Saâda¹, Michel Peoc'h, Anne-Valérie Decouvelaere, Olivier Collard, Annie-Claude Peyron, Florence Pedeutour

Affiliation

¹ Laboratory of Solid Tumors Genetics, Nice University Hospital, and Faculty of Medicine, University of Nice Sophia-Antipolis, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6543, Nice, France.

PMID: 21098327
DOI: 10.1200/JCO.2010.31.4286

No abstract available

Publication types

Case Reports

MeSH terms

Adult
Biopsy
Bone Transplantation
Cell Transformation, Neoplastic / genetics*
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 7*
Curettage
Cyclin D1 / genetics*
Female
Femoral Neoplasms / genetics*
Femoral Neoplasms / pathology
Femoral Neoplasms / surgery
Gene Amplification*
Giant Cell Tumor of Bone / genetics*
Giant Cell Tumor of Bone / pathology
Giant Cell Tumor of Bone / surgery
Humans
Immunohistochemistry
Karyotyping
Neoplasm Invasiveness
Proto-Oncogene Proteins c-met / genetics*
Receptors, Growth Factor / genetics*
Treatment Outcome

Substances

CCND1 protein, human
Receptors, Growth Factor
Cyclin D1
MET protein, human
Proto-Oncogene Proteins c-met