Abstract
Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.
Copyright © 2010 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Adjuvants, Immunologic / administration & dosage*
-
Adjuvants, Immunologic / adverse effects
-
Aluminum Hydroxide / administration & dosage
-
Aluminum Hydroxide / adverse effects
-
Animals
-
Anthrax / prevention & control
-
Anthrax Vaccines / adverse effects
-
Anthrax Vaccines / immunology*
-
Antibodies, Bacterial / blood
-
Antibodies, Neutralizing / blood
-
Liposomes / administration & dosage*
-
Liposomes / adverse effects
-
Macaca mulatta
-
Primate Diseases / prevention & control
-
Survival Analysis
Substances
-
Adjuvants, Immunologic
-
Anthrax Vaccines
-
Antibodies, Bacterial
-
Antibodies, Neutralizing
-
Liposomes
-
Aluminum Hydroxide