Abstract
Nineteen patients with panic disorder received sodium D,L-lactate (racemic) and pure sodium D-lactate infusions in a pilot study. Sodium D-lactate, which is less metabolically active than L-lactate, produced panic attacks in half the patients. D-Lactate also produced hypocapnia and alkalosis, indicating hyperventilation. These findings suggest that metabolism of lactate is not necessary for the induction of panic in susceptible patients. D-Lactate appears similar to other agents that cause panic in its capacity to stimulate respiration in the preliminary study.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Agoraphobia / physiopathology
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Bicarbonates / blood
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Blood Pressure / drug effects
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Calcium / blood
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Carbon Dioxide / blood
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Fear*
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Female
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Heart Rate / drug effects
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Humans
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Hyperventilation / chemically induced
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Hyperventilation / physiopathology
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Infusions, Intravenous
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Lactates / administration & dosage*
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Lactates / blood
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Lactates / pharmacology
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Lactic Acid
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Male
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Panic*
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Phobic Disorders / chemically induced
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Phobic Disorders / physiopathology*
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Phosphates / blood
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Pilot Projects
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Pyruvates / blood
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Pyruvic Acid
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Stereoisomerism
Substances
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Bicarbonates
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Lactates
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Phosphates
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Pyruvates
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Carbon Dioxide
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Lactic Acid
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Pyruvic Acid
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Calcium