Abstract
A human cDNA encoding a novel protein in the helix-loop-helix family has been isolated by screening a bacteriophage expression library with a probe containing the binding site for major late transcription factor. The protein encoded by this cDNA, TFEB, probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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DNA / genetics
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DNA / isolation & purification
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DNA-Binding Proteins / genetics*
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Enhancer Elements, Genetic
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Humans
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Immunoblotting
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Immunoglobulin Heavy Chains / genetics
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Lymphokines / genetics*
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Molecular Sequence Data
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Neoplasm Proteins*
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Prostatic Secretory Proteins*
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Sequence Homology, Nucleic Acid
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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DNA-Binding Proteins
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Immunoglobulin Heavy Chains
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Lymphokines
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Neoplasm Proteins
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Prostatic Secretory Proteins
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TFEB protein, human
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Transcription Factors
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beta-microseminoprotein
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immunoglobulin-binding factors
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DNA