A proliferation-inducing ligand (APRIL): the development of antagonistic agents as potential therapeutics and deciphering the role of heparan sulphate proteoglycans (HSPGs) in APRIL Signalling

Adv Exp Med Biol. 2011:691:501-6. doi: 10.1007/978-1-4419-6612-4_52.

Authors

Fiona Kimberley¹, Marco Guadagnoli, Hans van Eenennaam, Jan Paul Medema

Affiliation

¹ LEXOR (Laboratory of Experimental Oncology and Radiobiology), Center for Experimental Molecular Medicine, Academic Medical Center (AMC), University of Amsterdam, Room G2-140, 1105 AZ, Amsterdam, The Netherlands.

PMID: 21153355
DOI: 10.1007/978-1-4419-6612-4_52

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Monoclonal / pharmacology*
Antibodies, Monoclonal / therapeutic use*
Drug Discovery*
Heparan Sulfate Proteoglycans / metabolism*
Humans
Mice
Signal Transduction / drug effects*
Tumor Necrosis Factor Ligand Superfamily Member 13 / antagonists & inhibitors*
Tumor Necrosis Factor Ligand Superfamily Member 13 / metabolism*

Substances

Antibodies, Monoclonal
Heparan Sulfate Proteoglycans
Tumor Necrosis Factor Ligand Superfamily Member 13