YKL-40, a new biomarker of endothelial dysfunction, is independently associated with albuminuria in type 2 diabetic patients

Tetsuyuki Yasuda; Hideaki Kaneto; Naoto Katakami; Akio Kuroda; Taka-Aki Matsuoka; Yoshimitsu Yamasaki; Munehide Matsuhisa; Iichiro Shimomura

doi:10.1016/j.diabres.2010.11.015

YKL-40, a new biomarker of endothelial dysfunction, is independently associated with albuminuria in type 2 diabetic patients

Diabetes Res Clin Pract. 2011 Feb;91(2):e50-2. doi: 10.1016/j.diabres.2010.11.015. Epub 2010 Dec 15.

Authors

Tetsuyuki Yasuda¹, Hideaki Kaneto, Naoto Katakami, Akio Kuroda, Taka-Aki Matsuoka, Yoshimitsu Yamasaki, Munehide Matsuhisa, Iichiro Shimomura

Affiliation

¹ Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

PMID: 21159401
DOI: 10.1016/j.diabres.2010.11.015

Abstract

The aim of this study was to examine the possible association between YKL-40, a new biomarker of endothelial dysfunction, and albuminuria in 180 type 2 diabetic patients. Multivariate logistic regression analyses demonstrated that serum YKL-40 level was a determinant of albuminuria independently of conventional risk factors.

MeSH terms

Adipokines
Aged
Albuminuria / blood*
Chitinase-3-Like Protein 1
Diabetes Mellitus, Type 2 / blood*
Female
Glycoproteins / blood*
Humans
Lectins / blood*
Male
Middle Aged
Risk Factors

Substances

Adipokines
CHI3L1 protein, human
Chitinase-3-Like Protein 1
Glycoproteins
Lectins