Abstract
Synthetic associations have been posited as a possible explanation for missing heritability in complex disease. We show several lines of evidence which suggest that, while possible, these synthetic associations are not common.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
MeSH terms
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Computer Simulation
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Crohn Disease / genetics
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Genetic Linkage
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Genetic Loci
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Genetic Variation
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Genetics, Population
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Genome-Wide Association Study*
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Humans
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Models, Genetic*
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Nod2 Signaling Adaptor Protein / genetics
Substances
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NOD2 protein, human
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Nod2 Signaling Adaptor Protein