Melampomagnolide B: a new antileukemic sesquiterpene

Shama Nasim; ShanShan Pei; Fred K Hagen; Craig T Jordan; Peter A Crooks

doi:10.1016/j.bmc.2010.12.045

Melampomagnolide B: a new antileukemic sesquiterpene

Bioorg Med Chem. 2011 Feb 15;19(4):1515-9. doi: 10.1016/j.bmc.2010.12.045. Epub 2011 Jan 6.

Authors

Shama Nasim¹, ShanShan Pei, Fred K Hagen, Craig T Jordan, Peter A Crooks

Affiliation

¹ Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.

PMID: 21273084
DOI: 10.1016/j.bmc.2010.12.045

Abstract

Melampomagnolide B has been identified as a new antileukemic sesquiterpene. A biotin-conjugated derivative of melampomagnolide B was designed and synthesized in order to elucidate its mechanism of action. A study of the biochemical interactions of the biotin probe suggests that melampomagnolide B derives its remarkable selectivity for leukemic cells over normal hematopoietic cells from its unique ability to exploit biochemical differences between the two cell types.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Cell Survival / drug effects
Humans
Leukemia / drug therapy*
Molecular Structure
Sesquiterpenes / chemical synthesis*
Sesquiterpenes / pharmacology*
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Sesquiterpenes
melampomagnolide B