Abstract
Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 (HIV-1) was used to immunize chimpanzees. The animals developed high titers of antibodies to p55 as well as to the p24 and p17 mature cleavage products of the core precursor. Virus-neutralizing antibodies were not elicited. The induced immune responses did not prevent establishment of HIV-1 infection following challenge of one immunized chimpanzee with live virus.
MeSH terms
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Animals
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Gene Products, gag / genetics
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Gene Products, gag / immunology*
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HIV Antibodies / biosynthesis*
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HIV Antigens / immunology*
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HIV Core Protein p24
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HIV Envelope Protein gp41 / immunology
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HIV Infections / immunology*
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HIV Infections / prevention & control
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Immunization
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Neutralization Tests
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Pan troglodytes
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Protein Precursors / genetics
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Protein Precursors / immunology*
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Recombinant Proteins / immunology
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Saccharomyces cerevisiae / genetics
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Viral Core Proteins / immunology
Substances
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Gene Products, gag
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HIV Antibodies
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HIV Antigens
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HIV Core Protein p24
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HIV Envelope Protein gp41
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Protein Precursors
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Recombinant Proteins
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Viral Core Proteins
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p55 gag precursor protein, Human immunodeficiency virus 1