Abstract
Disulfiram is commonly used in the treatment of alcohol dependence. It induces aversive symptoms after alcohol ingestion: the "acetaldehyde syndrome". Most often "acetaldehyde syndrome" is moderate but severe life-threatening symptoms may occur in specific circumstances. We report the case of a serious "acetaldehyde syndrome" with shock compounded by the initial administration of dopamine. Discussion clarifies the pathophysiology and develops the therapeutic management.
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Acetaldehyde / adverse effects*
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Alcohol Deterrents / adverse effects*
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Alcoholic Intoxication / complications
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Alcoholism / complications
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Alcoholism / drug therapy
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Anti-Anxiety Agents / therapeutic use
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Antidepressive Agents / therapeutic use
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Bipolar Disorder / complications
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Bipolar Disorder / drug therapy
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Cardiotonic Agents / adverse effects*
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Central Nervous System Depressants / adverse effects
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Disulfiram / adverse effects*
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Dopamine / adverse effects*
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Electrocardiography
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Ethanol / adverse effects
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Humans
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Hypokalemia / chemically induced
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Hypokalemia / therapy
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Male
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Middle Aged
Substances
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Alcohol Deterrents
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Anti-Anxiety Agents
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Antidepressive Agents
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Cardiotonic Agents
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Central Nervous System Depressants
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Ethanol
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Acetaldehyde
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Disulfiram
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Dopamine