Role of decoy molecules in neuronal ischemic preconditioning

Life Sci. 2011 Apr 11;88(15-16):670-4. doi: 10.1016/j.lfs.2011.02.004. Epub 2011 Feb 20.

Abstract

Aims: Decoy receptors bind with TNF related apoptosis inducing ligands (TRAIL) but do not contain the cytoplasmic domains necessary to transduce apoptotic signals. We hypothesized that decoy receptors may confer neuronal protection against lethal ischemia after ischemic preconditioning (IPC).

Main method: Mixed cortical neurons were exposed to IPC one day prior to TRAIL treatment or lethal ischemia.

Key findings: IPC increased decoy receptor but reduced death receptor expression compared to lethal ischemia. IPC-induced increase in decoy receptor expression was reduced by prior treatment with CAPE, a nuclear factor-kappa B inhibitor (NFκB).

Significance: Expression of decoy molecules, dependent on NFκB, may mediate neuronal survival induced by IPC.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Animals, Newborn
  • Apoptosis
  • Caffeic Acids / pharmacology
  • Cerebral Cortex / metabolism
  • Gene Expression Regulation
  • Ischemic Preconditioning / methods*
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism
  • Neurons / metabolism*
  • Phenylethyl Alcohol / analogs & derivatives
  • Phenylethyl Alcohol / pharmacology
  • Rats
  • Receptors, Death Domain / metabolism
  • TNF-Related Apoptosis-Inducing Ligand / metabolism*
  • Tumor Necrosis Factor Decoy Receptors / metabolism*

Substances

  • Caffeic Acids
  • NF-kappa B
  • Receptors, Death Domain
  • TNF-Related Apoptosis-Inducing Ligand
  • Tumor Necrosis Factor Decoy Receptors
  • caffeic acid phenethyl ester
  • Phenylethyl Alcohol