Conservation of fruitless' role as master regulator of male courtship behaviour from cockroaches to flies

Dev Genes Evol. 2011 May;221(1):43-8. doi: 10.1007/s00427-011-0352-x. Epub 2011 Feb 22.

Abstract

In Drosophila melanogaster, male courtship behaviour is regulated by the fruitless gene. In D. melanogaster, fruitless encodes a set of putative transcription factors that are sex-specifically spliced. Male-specific variants are necessary and sufficient to elicit male courtship behaviour. Fruitless sequences have been reported in other insect species, but there are no data available on their functional role. In the present work, we cloned and sequenced fruitless in males of the German cockroach, Blattella germanica, and we studied its expression in male brain and testes. B. germanica fruitless encodes a 350-amino acid protein with BTB and Zinc finger domains typical of fruitless sequences. Upon RNAi-mediated knockdown of fruitless in B. germanica, males no longer exhibit courtship behaviour, thus implying that fruitless is necessary for male sexual behaviour in our cockroach model. This suggests that the role of fruitless as master regulator of male sexual behaviour has been conserved along insect evolution, at least from cockroaches to flies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Biological Evolution
  • Cockroaches / genetics*
  • Cockroaches / metabolism
  • Courtship*
  • Drosophila Proteins / genetics*
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / metabolism
  • Male
  • Nerve Tissue Proteins / genetics*
  • Nerve Tissue Proteins / metabolism
  • RNA Interference / physiology
  • RNA Splicing
  • Sexual Behavior, Animal / physiology*
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Zinc Fingers / genetics

Substances

  • Drosophila Proteins
  • Nerve Tissue Proteins
  • Transcription Factors
  • fru protein, Drosophila