Isolation of a novel Aggregatibacter actinomycetemcomitans serotype b bacteriophage capable of lysing bacteria within a biofilm

Appl Environ Microbiol. 2011 May;77(9):3157-9. doi: 10.1128/AEM.02115-10. Epub 2011 Mar 4.

Abstract

A bacteriophage specific for Aggregatibacter actinomycetemcomitans serotype b, able to kill the bacterium within a biofilm, was isolated. Random mutagenesis of this phage rendered a bacteriophage able to kill 99% of the bacteria within a biofilm. This is the first report of a biocontrol experiment against A. actinomycetemcomitans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteriolysis*
  • Bacteriophages / drug effects
  • Bacteriophages / growth & development*
  • Bacteriophages / isolation & purification*
  • Biofilms / growth & development*
  • Mutagenesis
  • Mutagens / metabolism
  • Pasteurellaceae / growth & development*
  • Pasteurellaceae / virology*
  • Pest Control, Biological / methods

Substances

  • Mutagens