Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery

J Med Chem. 2011 Apr 14;54(7):1961-2004. doi: 10.1021/jm1012374. Epub 2011 Mar 7.
No abstract available

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cyclization
  • Drug Discovery / methods*
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Macrocyclic Compounds / chemical synthesis*
  • Macrocyclic Compounds / chemistry
  • Macrocyclic Compounds / pharmacology*
  • Protein Binding / drug effects
  • Receptors, G-Protein-Coupled / metabolism

Substances

  • Enzyme Inhibitors
  • Macrocyclic Compounds
  • Receptors, G-Protein-Coupled