Studies on the biologic activities of Sandimmun metabolites in humans and in animal models: review and original experiments

Transplant Proc. 1990 Jun;22(3):1116-24.

Authors

A Fahr¹, P Hiestand, B Ryffel

Affiliation

¹ Department of Pharmacological Development, Sandoz Pharmaceuticals Ltd, Basel, Switzerland.

PMID: 2140916

No abstract available

MeSH terms

Animals
Cyclosporins / pharmacokinetics
Cyclosporins / pharmacology*
Gene Expression Regulation / drug effects
Humans
Immune Tolerance / drug effects
Immunosuppressive Agents / pharmacology*
Interleukin-2 / genetics
Lymphocyte Activation / drug effects*
Lymphocyte Culture Test, Mixed
Mice
Mice, Inbred Strains
RNA, Messenger / drug effects
Structure-Activity Relationship
T-Lymphocytes / drug effects

Substances

Cyclosporins
Immunosuppressive Agents
Interleukin-2
RNA, Messenger