Increasing West Nile virus antibody titres in central European plasma donors from 2006 to 2010

P O Rabel; C B Planitzer; M R Farcet; K K Orlinger; R Ilk; P N Barrett; T R Kreil

doi:10.2807/ese.16.10.19812-en

Increasing West Nile virus antibody titres in central European plasma donors from 2006 to 2010

Euro Surveill. 2011 Mar 10;16(10):19812. doi: 10.2807/ese.16.10.19812-en.

Authors

P O Rabel¹, C B Planitzer, M R Farcet, K K Orlinger, R Ilk, P N Barrett, T R Kreil

Affiliation

¹ Baxter BioScience, Vienna, Austria.

PMID: 21435324
DOI: 10.2807/ese.16.10.19812-en

Abstract

We analysed by neutralisation assay 55 intravenous immunoglobulin preparations produced from human plasma collected in three central European countries, specifically Austria, Germany and the Czech Republic, from 2006 to 2010. The preparations from 2009 and 2010 contained increasing titres of neutralising antibodies against West Nile virus (WNV) in the absence of reported human WNV cases in these countries.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral / blood*
Austria
Blood Donors
Czech Republic
Germany
Humans
Immunoglobulin G / blood
Immunoglobulins, Intravenous / pharmacology*
Immunologic Factors / pharmacology*
Neutralization Tests
Viral Load
West Nile Fever / blood
West Nile Fever / immunology*
West Nile Fever / virology
West Nile virus / drug effects
West Nile virus / immunology*

Substances

Antibodies, Neutralizing
Antibodies, Viral
Immunoglobulin G
Immunoglobulins, Intravenous
Immunologic Factors