Abstract
In this study, we investigated the effects of S-allyl-L-cysteine (SAC), a major sulfur-containing compound present in garlic, on Ki67- and doublecortin (DCX)-positive cells, which were used as a marker for cell proliferation and neuroblast differentiation, respectively, in the mouse dentate gyrus. SAC (300 mg/kg) was intraperitoneally administered to 8-week-old mice once a day for 3 weeks. The animals were then sacrificed at 11 weeks of age. SAC administration significantly increased Ki67-positive nuclei and DCX-immunoreactive neuroblasts in the subgranular zone of the dentate gyrus. Furthermore, serotonin 1A receptor (5-HT(1A)) levels in the hippocampus were also increased. These results suggest that SAC significantly increased cell proliferation and neuroblast differentiation by increasing 5-HT(1A) levels in the dentate gyrus.
MeSH terms
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Animals
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Biomarkers / metabolism
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Cell Proliferation / drug effects*
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Central Nervous System Agents / administration & dosage
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Central Nervous System Agents / pharmacology*
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Cysteine / administration & dosage
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Cysteine / analogs & derivatives*
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Cysteine / pharmacology
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Dentate Gyrus / cytology
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Dentate Gyrus / drug effects*
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Dentate Gyrus / metabolism
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Doublecortin Domain Proteins
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Doublecortin Protein
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Drug Administration Schedule
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Ki-67 Antigen / metabolism
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Male
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Mice
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Mice, Inbred C57BL
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Microtubule-Associated Proteins / metabolism
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Neurogenesis / drug effects*
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Neuropeptides / metabolism
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Receptor, Serotonin, 5-HT1A / metabolism
Substances
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Biomarkers
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Central Nervous System Agents
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Dcx protein, mouse
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Doublecortin Domain Proteins
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Doublecortin Protein
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Ki-67 Antigen
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Microtubule-Associated Proteins
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Neuropeptides
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Receptor, Serotonin, 5-HT1A
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S-allylcysteine
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Cysteine