SUMmOning Daxx-mediated repression

Debaditya Mukhopadhyay; Michael J Matunis

doi:10.1016/j.molcel.2011.03.008

SUMmOning Daxx-mediated repression

Mol Cell. 2011 Apr 8;42(1):4-5. doi: 10.1016/j.molcel.2011.03.008.

Authors

Debaditya Mukhopadhyay¹, Michael J Matunis

Affiliation

¹ Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

Abstract

An intimate relationship exists between the transcriptional coregulator Daxx, SUMO, and PML nuclear bodies. In this issue, Chang et al. (2011) provide structural insights into how phosphorylation of Daxx increases its affinity toward SUMOs and functional insights into how enhanced SUMO binding affects Daxx-PML interactions, PML nuclear body localization, and Daxx-mediated repression of genes encoding for antiapoptotic factors.

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