Development of echinocandin resistance in Clavispora lusitaniae during caspofungin treatment

J Clin Microbiol. 2011 Jun;49(6):2304-6. doi: 10.1128/JCM.00325-11. Epub 2011 Apr 13.

Abstract

Clavispora lusitaniae is an opportunistic human pathogen responsible for 0.6 to 2% of candidemia. This species is intrinsically susceptible to echinocandins. Nevertheless, in this study, development of echinocandin resistance in C. lusitaniae isolates was observed during caspofungin treatment. This resistance resulted from missense mutation in the echinocandin target Fks1 gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Amino Acid Substitution / genetics
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / pharmacology*
  • Caspofungin
  • DNA Mutational Analysis
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • Drug Resistance, Fungal*
  • Echinocandins / administration & dosage
  • Echinocandins / pharmacology*
  • Glucosyltransferases / genetics
  • Humans
  • Lipopeptides
  • Male
  • Molecular Sequence Data
  • Mutation, Missense
  • Mycoses / drug therapy*
  • Mycoses / microbiology*
  • Saccharomycetales / drug effects*
  • Sequence Analysis, DNA

Substances

  • Antifungal Agents
  • DNA, Fungal
  • Echinocandins
  • Lipopeptides
  • Glucosyltransferases
  • Caspofungin

Associated data

  • GENBANK/JF304613
  • GENBANK/JF304614
  • GENBANK/JF304615