Once the experience of GISSI I was concluded, the as yet unresolved problem of the choice of one fibrinolytic agent in preference to others emerged. In the present study, the authors used echocardiography in order to compare streptokinase with r-TPA in order to limit myocardial damage in acute myocardial infarction in 33 patients, average age 64.6 years. No statistically significant difference between the two drugs was observed as far as left ventricular contractility and extent of the infarcted region was concerned. This was in accordance with the findings of the Italian PAIMS study.