Abstract
Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We, therefore, tested gabapentin on PIDs and stroke outcome. Gabapentin pretreatment (200 mg/kg, intravenously) reduced the infarct volume by 23% after transient focal ischemia in mice. However, the frequency and duration of PIDs were not suppressed when recorded for 2 hours during ischemia, suggesting that gabapentin reduces infarct volume independent of PID suppression.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / therapeutic use*
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Animals
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Anticonvulsants / therapeutic use*
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Brain / drug effects*
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Brain / pathology*
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Brain / physiopathology
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Brain Infarction / pathology
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Brain Infarction / physiopathology
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Brain Infarction / prevention & control
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Brain Ischemia / pathology*
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Brain Ischemia / physiopathology
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Brain Ischemia / prevention & control*
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Cortical Spreading Depression / drug effects
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Cyclohexanecarboxylic Acids / therapeutic use*
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Gabapentin
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Ischemic Attack, Transient / pathology
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Ischemic Attack, Transient / physiopathology
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Ischemic Attack, Transient / prevention & control
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Male
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Mice
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Mice, Inbred C57BL
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gamma-Aminobutyric Acid / therapeutic use*
Substances
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Amines
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Anticonvulsants
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Cyclohexanecarboxylic Acids
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gamma-Aminobutyric Acid
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Gabapentin