Discovery of orally active, potent, and selective benzotriazole-based PTP1B inhibitors

MeSH terms

• Administration, Oral
• Animals
• Diabetes Mellitus / drug therapy*
• Enzyme Inhibitors / chemistry*
• Enzyme Inhibitors / pharmacokinetics
• Enzyme Inhibitors / pharmacology
• Enzyme Inhibitors / therapeutic use*
• Humans
• Hypoglycemic Agents / chemistry*
• Hypoglycemic Agents / pharmacokinetics
• Hypoglycemic Agents / pharmacology
• Hypoglycemic Agents / therapeutic use*
• Male
• Mice
• Mice, Inbred C57BL
• Models, Molecular
• Protein Binding
• Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
• Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism
• Rats
• Rats, Wistar
• Structure-Activity Relationship
• Triazoles / chemistry*
• Triazoles / pharmacokinetics
• Triazoles / pharmacology
• Triazoles / therapeutic use*