Primary graft dysfunction

Clin Chest Med. 2011 Jun;32(2):279-93. doi: 10.1016/j.ccm.2011.02.007.

Abstract

Primary graft dysfunction (PGD) is the most important cause of early morbidity and mortality following lung transplantation. PGD affects up to 25% of all lung transplant procedures and currently has no proven preventive therapy. Lung transplant recipients who recover from PGD may have impaired long-term function and an increased risk of bronchiolitis obliterans syndrome. This article aims to provide a state-of-the-art review of PGD epidemiology, outcomes, and risk factors, and to summarize current efforts at biomarker development and novel strategies for prevention and treatment.

Publication types

  • Review

MeSH terms

  • Biomarkers / blood
  • Humans
  • Lung Transplantation*
  • Primary Graft Dysfunction* / diagnosis
  • Primary Graft Dysfunction* / epidemiology
  • Primary Graft Dysfunction* / etiology
  • Primary Graft Dysfunction* / therapy
  • Risk Factors

Substances

  • Biomarkers