Genetics of atopic dermatitis
J Dtsch Dermatol Ges. 2011 Sep;9(9):670-6.
doi: 10.1111/j.1610-0387.2011.07656.x.
Epub 2011 Apr 26.
[Article in
English,
German]
Affiliation
- 1 Department of Dermatology and Allergy, University of Bonn, Germany.
Abstract
Atopic dermatitis (AD) is a multifactorial disease, with a strong genetic predisposition. Genome-wide studies as well as candidate gene studies revealed several susceptibility loci. Since the observation of a strong association of "loss of function" mutations in the filaggrin gene with AD, the epidermal barrier was rediscovered as important pathophysiological co-factor of this disease.
© The Authors • Journal compilation © Blackwell Verlag GmbH, Berlin.
MeSH terms
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Adaptive Immunity / genetics
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Alleles
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DNA Mutational Analysis
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Dermatitis, Atopic / diagnosis
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Dermatitis, Atopic / genetics*
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Diseases in Twins / genetics
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Filaggrin Proteins
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Gene Frequency / genetics
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Genetic Association Studies
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Genetic Predisposition to Disease / genetics*
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Genome-Wide Association Study
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Humans
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Immunity, Innate / genetics
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Immunoglobulin E / blood
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Intermediate Filament Proteins / genetics*
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Polymorphism, Single Nucleotide / genetics
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Risk Factors
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Skin / immunology
Substances
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FLG protein, human
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Filaggrin Proteins
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Intermediate Filament Proteins
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Immunoglobulin E