Background: The present study evaluated the effects of treadmill running on extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats.
Methods: After 12 weeks of diabetes induction and exercise period, extracellular levels of glutamate and GABA were investigated.
Results: The results showed that glutamate levels were significantly decreased in diabetes-rest group comparing to the control-rest and the diabetes-exercise groups.
Conclusions: The findings support the possibility that treadmill running is helpful in alleviating neurotransmitter homeostasis and alterations in transmission in diabetes mellitus.
Keywords: Dentate Gyrus; Diabetes; GABA; Glutamate; Hippocampus; Microdialysis; Streptozotocin; Treadmill Running.