Abstract
An efficient solution-phase parallel procedure to perform the structural diversification of some formyl-nitrogen heterocycles (A) using the reusable TBD supported base is described. The library synthesis is based in a consecutive Alkylation-Knoevenagel functionalisation that uses alkyl halides (B), Michael acceptors (C) and activated methylene compounds (D) as diversity elements.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Aza Compounds / chemical synthesis*
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Aza Compounds / chemistry
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Azabicyclo Compounds / chemistry*
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / chemistry
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High-Throughput Screening Assays
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Molecular Structure
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Solutions
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Stereoisomerism
Substances
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Aza Compounds
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Azabicyclo Compounds
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Heterocyclic Compounds
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Solutions
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triazabicyclodecene