Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging

Chem Commun (Camb). 2011 Jul 14;47(26):7500-2. doi: 10.1039/c1cc11253h. Epub 2011 May 9.

Abstract

A new small molecule probe for in vivo lipid imaging, LipidGreen (compound 5), was developed. LipidGreen stained lipid droplets in 3T3L1 cell lines and fat deposits in zebrafish without apparent toxicity up to 100 μM. The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells
  • Adipose Tissue / metabolism
  • Animals
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry*
  • Lipid Metabolism*
  • Mice
  • Molecular Imaging / methods*
  • Zebrafish

Substances

  • Fluorescent Dyes