Resorthiomycin, a novel antitumor antibiotic. I. Taxonomy, isolation and biological activity

H Suzuki; M Tahara; M Takahashi; F Matsumura; T Okabe; A Shimazu; A Hirata; H Yamaki; H Yamaguchi; N Tanaka

doi:10.7164/antibiotics.43.129

Resorthiomycin, a novel antitumor antibiotic. I. Taxonomy, isolation and biological activity

J Antibiot (Tokyo). 1990 Feb;43(2):129-34. doi: 10.7164/antibiotics.43.129.

Authors

H Suzuki¹, M Tahara, M Takahashi, F Matsumura, T Okabe, A Shimazu, A Hirata, H Yamaki, H Yamaguchi, N Tanaka, et al.

Affiliation

¹ Institute of Applied Microbiology, University of Tokyo, Japan.

PMID: 2155895
DOI: 10.7164/antibiotics.43.129

Abstract

Resorthiomycin, a novel antitumor antibiotic, was isolated from the fermentation broth of a strain of Streptomyces collinus by ethyl acetate extraction, silica gel chromatography and HPLC. Resorthiomycin exhibited an in vitro cytotoxic activity against mouse leukemia L5178Y cells (IC50, 15.5 micrograms/ml) and also inhibited the clonogenic activity of a multidrug-resistant mutant of human hepatoma PLC/PRF/5 cells to a greater extent than that of the parental cells. On the other hand, this antibiotic does not possess any antibacterial or antifungal activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibiotics, Antineoplastic / isolation & purification*
Carcinoma, Hepatocellular
Cell Line / drug effects
Chromatography, High Pressure Liquid
Humans
Leukemia L5178
Liver Neoplasms
Mice
Resorcinols / isolation & purification
Resorcinols / pharmacology
Streptomyces / analysis

Substances

Antibiotics, Antineoplastic
Resorcinols
resorthiomycin