Due to the progress made in implantology, in recent years the interest in prosthetic rehabilitation in edentulous mouths using overdentures has increased considerably. Indications to the treatment of implant supported overdenture could be classified in three groups: the first group consists of younger members of the elderly population who have an edentulous upper jaw rehabilitated with a conventional complete denture but experience discomfort with it and therefore desire a stable prosthesis and greater comfort in the mouth; the second group, for which the use of implant overdentures is recommended, consists of older patients who require greater stability from a complete mandibular denture; the third group consists of compromised patients and those with acquired or congenital maxillofacial conditions. Moreover, advantages of overdentures supported by implants are analyzed; in fact, they allow a lower bone reabsorption, a better retention and stability of the prosthesis than the traditional complete denture, an increased masticatory effectiveness, a reduction of pain during mastication tanks to the higher stability, a better sensory perception, a considerable patient satisfaction, and the option of making an immediate prosthetic rehabilitation with implants through immediate load.