Synthesis and in vitro protein tyrosine kinase inhibitory activity of furan-2-yl(phenyl)methanone derivatives

Fei Lang Zheng; Shu Rong Ban; Xiu E Feng; Cheng Xiao Zhao; Wenhan Lin; Qing Shan Li

doi:10.3390/molecules16064897

Synthesis and in vitro protein tyrosine kinase inhibitory activity of furan-2-yl(phenyl)methanone derivatives

Molecules. 2011 Jun 14;16(6):4897-911. doi: 10.3390/molecules16064897.

Authors

Fei Lang Zheng¹, Shu Rong Ban, Xiu E Feng, Cheng Xiao Zhao, Wenhan Lin, Qing Shan Li

Affiliation

¹ School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, Shanxi, China.

Abstract

A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of ¹H-NMR, ¹³C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / enzymology
Furans / chemical synthesis*
Furans / chemistry
Furans / pharmacology*
Nuclear Magnetic Resonance, Biomolecular
Protein Kinase Inhibitors / chemical synthesis*
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology*
Protein-Tyrosine Kinases / antagonists & inhibitors*
Rats
Structure-Activity Relationship

Substances

Furans
Protein Kinase Inhibitors
Protein-Tyrosine Kinases