Emergence of aminoglycoside resistance genes aadA and aadE in the genus Campylobacter

Antimicrob Agents Chemother. 1990 Jun;34(6):1294-6. doi: 10.1128/AAC.34.6.1294.

Abstract

Resistance to streptomycin or spectinomycin or both in five Campylobacter coli strains, two Campylobacter jejuni strains, and a Campylobacter-like strain was studied by enzymatic assays and dot blot hybridization. Resistance was due to 6- or 3",9-aminoglycoside adenylyltransferases and to new types of phospho- and adenylyltransferases.

MeSH terms

  • Campylobacter / drug effects
  • Campylobacter / genetics*
  • DNA, Bacterial / genetics
  • Drug Resistance, Microbial / genetics
  • Genes, Bacterial / physiology*
  • Microbial Sensitivity Tests
  • Nucleic Acid Hybridization
  • Nucleotidyltransferases / genetics
  • Spectinomycin / pharmacology*
  • Streptomycin / pharmacology*

Substances

  • DNA, Bacterial
  • Spectinomycin
  • Nucleotidyltransferases
  • glutamine-synthetase adenylyltransferase
  • Streptomycin